Tell your doctor if you have or have ever had anemia red blood cells do not bring enough oxygen to all parts of the body. Dose adjustment is recommended for patients with renal insufficiency. Ganciclovir is eliminated primarily through the kidneys and excreted as active drug in the urine. It is first phosphorylated to ganciclovir monophosphate by a viral kinase encoded by the cytomegalovirus cmv gene ul97 during infection.
If you are 65 or older, use ganciclovir systemic with care. Ganciclovir e contraindicado a pacientes com hipersensibilidade ao ganciclovir, valganciclovir ou qualquer outro componente da formula. Ganciclovir is a prescription medicine approved by the u. Ganciclovir dosificacion, efectos secundarios infosida.
Cymevene ganciclovir sodico antiviroticos identificacao do. Cytovene, ganciclovir dosing, indications, interactions. Cytoveneiv ganciclovir, formulated as monosodium salt, using sodium hydroxide as a salt forming agent, is a sterile white to offwhite lyophilized powder. Ganciclovir is a polar hydrophilic compound with a solubility of 2. O ganciclovir sodico e preparado como um po liofilizado esteril com uma solubilidade em agua excedendo 100 mgml. Nov 09, 2018 ganciclovir is an antiviral drug that slows the growth and spread of the cytomegalovirus cmv. Feb 03, 2020 if you are 65 or older, use ganciclovir systemic with care. Find patient medical information for ganciclovir ophthalmic eye on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Ganciclovir may lower the number of all types of cells in your blood, causing serious and lifethreatening problems. Ganciclovir is a white to offwhite crystalline powder with a molecular formula of c 9 h n 5 0 4 and a molecular weight of 255. In addition, ganciclovir triphosphate serves as a poor substrate for chain elongation, thereby disrupting viral dna synthesis by a second route. Ganciclovir is widely distributed throughout the body and achieves csf concentrations that are 24% to 70% of plasma concentrations. Esse mecanismo pode prevenir a doenca causada pelo citomegalovirus em pacientes com sistema imunologico debilitado ou pode diminuir a progressao da retinite. It is widely used for the treatment of cmv infections among patients with impaired cellmediated immunity, particularly persons with poorly controlled and advanced hivaids, and recipients of solid organ and bone marrow transplantation, who are at high risk for invasive cmv.
Ganciclovir is also used to prevent cmv disease in people with immunosuppression due to an organ transplant. Subsequently, cellular kinases catalyze the formation of ganciclovir diphosphate and ganciclovir triphosphate, which is present in 10fold greater. Food and drug administration fda for the treatment of cytomegalovirus retinitis cmv retinitis in individuals with aids. Ganciclovir is used to treat cmv retinitis in people with immunosuppression caused by hiv or aids. Dec 21, 2018 whether ganciclovir can harm a human baby has not been fully studied. Cymevene, ganciclovir, infeccion por cmv, solucion, roche, rx. Ganciclovir is also fdaapproved for the prevention of cmv disease in recipients of organ transplants who are at risk for cmv diseases. Ganciclovir triphosphate is a competitive inhibitor of deoxyguanosine triphosphate dgtp incorporation into dna and preferentially inhibits viral dna polymerases more than cellular dna polymerases. Women must use birth control while taking ganciclovir systemic and for some time after the last.
Ganciclovir is also used to prevent cytomegalovirus cmv disease in people who have acquired immunodeficiency syndrome aids or who have received an organ transplant and are at risk of cmv disease. Ganciclovir triphosphate is a competitive inhibitor of deoxyguanosine triphosphate incorporation into dna and preferentially inhibits viral dna polymerases more than cellular dna polymerases. Ganciclovir is in a class of medications called antivirals. Find patient medical information for ganciclovir sodium intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Ganciclovir indicaciones, dosificacion, presentacion. In a study of ganciclovir for injection treatment of life or sightthreatening cmv disease in immunocompromised patients, 121 of 314 patients had cmv cultured within 7 days prior to treatment and sequential posttreatment viral cultures of urine, blood, throat andor semen. Ganciclovir is also used to prevent cmv disease in people with. It works by preventing the spread of cmv disease or slowing the growth of cmv. Composicion, indicaciones, presentacion y contraindicaciones.
Ganciclovir is an antiviral drug that slows the growth and spread of the cytomegalovirus cmv. Ganciclovir is used to treat cmv retinitis in people with immunosuppression caused by. Ganciclovir oral and injectable oral and injectable. To prevent pregnancy while taking ganciclovir, women should use the birth control of their choice and men should use condoms during treatment and for 90 days after ending treatment. A pregnancy test will be done before you start ganciclovir systemic to show that you are not pregnant.
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